p 150: the role of blood brain barrier restoration in the multiple sclerosis
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abstract
blood brain barrier (bbb) is a specialized non fenestrate barrier that formation by the endothelial cells and controls the transportation of the cells and molecules in to the brain. reducing in function of bbb is one of disruptions in neurological diseases like multiple sclerosis. endothelial progenitor cell (epc) help to the bbb to control the diapedesis of inflammatory cells & molecules in to the brain with decrease icam-1 in blood. however they increase angiogenesis around the bbb. multipotent adult progenitor cells (mapcs) increase the proliferation of the m2 macrophage-like cells and apoptosis of the m1 macrophage-like cells at 3-7 days after transplantation. however this mechanism of mapcs decrease the inflammation of the central nervous system (cns) and bbb but because of the short acting time, it's not very useful. mesenchymal stem cells (msc) are of the mainly hope to repair bbb. they can balancing surface of the b-catenin and cadherin. this balance can create some tight junctions in to the bbb to help controlling the transportation. in addition they can increase secretion of the metalloproteinase -3 which can improve the function of the bbb. hematopoietic stem cells are the one the best candid for ms treatment. they can restart immune system to control proinflammatory mediators. they also can decrees the expression of the cd8 & cd4 to prevent of developing of inflammation. however there are many studies to investigated cell therapy and its effect on cns, there is no powerful study to peruse cell therapy for restoration of the bbb in multiple sclerosis. we suggest to study on it as an individual treatment.
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P 150: The Role of Blood Brain Barrier Restoration in the Multiple Sclerosis
Blood Brain Barrier (BBB) is a specialized non fenestrate barrier that formation by the endothelial cells and controls the transportation of the cells and molecules in to the brain. Reducing in function of BBB is one of disruptions in neurological diseases like multiple sclerosis. Endothelial progenitor cell (EPC) help to the BBB to control the diapedesis of inflammatory cells & molecules in to...
full textP 136: The Role of Blood Brain Barrier in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory disorder, in which neurons become demyelinated. To date, its etiology has remained unknown. Nevertheless, certain features are inspected to provoke MS. For instance, improper function of immune cells is widely believed to be the basis of such disorder. In this concept, MS is stated as an autoimmune disease, which was asserted by major of studies, as CD...
full textp 136: the role of blood brain barrier in multiple sclerosis
multiple sclerosis (ms) is an inflammatory disorder, in which neurons become demyelinated. to date, its etiology has remained unknown. nevertheless, certain features are inspected to provoke ms. for instance, improper function of immune cells is widely believed to be the basis of such disorder. in this concept, ms is stated as an autoimmune disease, which was asserted by major of studies, as cd...
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full textBlood-brain barrier disruption in multiple sclerosis.
The blood-brain barrier (BBB) is a complex organization of cerebral endothelial cells (CEC), pericytes and their basal lamina, which are surrounded and supported by astrocytes and perivascular macrophages. Collectively these cells separate and form the compartments of the cerebral vascular space and the cerebral interstitium under normal conditions. Without the BBB, the 'interior milieu' of the...
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Journal title:
مجله علوم اعصاب شفای خاتمجلد ۵، شماره ۲، صفحات ۱۸۱-۱۸۱
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